Other tumors


Editorial Board Member: Aaron R. Huber, D.O.
Deputy Editor-in-Chief: Catherine E. Hagen, M.D.
Irene Y. Chen, M.D.
Diana Agostini-Vulaj, D.O.

Last author update: 20 July 2022
Last staff update: 15 August 2023

Copyright: 2019-2023,, Inc.

PubMed Search: Gastroblastoma

Irene Y. Chen, M.D.
Diana Agostini-Vulaj, D.O.
Page views in 2022: 3,117
Page views in 2023 to date: 3,559
Cite this page: Chen IY, Agostini-Vulaj D. Gastroblastoma. website. Accessed November 29th, 2023.
Definition / general
Essential features
  • Rare, biphasic epitheliomesenchymal neoplasm of the stomach
  • Majority of cases have characteristic fusion gene, MALAT1::GLI1
  • Novel EWSR1::CTBP1 fusion was recently identified
  • Mostly seen in young adults
ICD coding
  • ICD-O: 8976/3 - gastroblastoma
  • ICD-11: 2F70.1 & XH4VQ1 - neoplasms of uncertain behavior of stomach & gastroblastoma
  • Unknown
Clinical features
  • Imaging followed by tissue diagnosis
Radiology description
Radiology images

Images hosted on other servers:

CT and MRI with multilobulated cystic mass

Prognostic factors
  • Unknown at this time
Case reports
Clinical images

Images hosted on other servers:

Lobulated stomach mass

Gross description
Gross images

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Solid and cystic mass

Variegated mass

Transmural mass

Microscopic (histologic) description
  • Biphasic tumor
    • Spindle cell component demonstrating sheets of monotonous spindled type cells
    • Epithelial component demonstrating cords / clusters of epithelial type cells, some with vague to well formed gland formation, which may contain inspissated material
  • Relatively low mitotic rate (Am J Surg Pathol 2009;33:1370)
Microscopic (histologic) images

Contributed by Raul S. Gonzalez, M.D. and Rondell P. Graham, M.B.B.S.

Invasive tumor

Epithelial component

Nests of epithelioid cells

Spindle cell component

Positive stains
Negative stains
Electron microscopy description
Electron microscopy images

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Desmosomes and microvilli between tumor cells

Molecular / cytogenetics description
Molecular / cytogenetics images

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RT-PCR, MALAT1::GLI1 fusion and sequencing

breakapart and
fusion FISH

Sample pathology report
  • Stomach, partial gastrectomy:
    • Gastroblastoma (see comment)
    • Comment: H&E sections demonstrate a biphasic tumor with varied intermixed epithelial and stromal elements. The epithelial component is positive for keratin AE1 / AE3 while the stromal component is positive for vimentin. Both components are negative for KIT, CD34, desmin, S100, CD99 and SMA. Additional ancillary testing demonstrates the MALAT1::GLI1 fusion gene.
Differential diagnosis
Board review style question #1
Which fusion gene typifies gastroblastoma?

  1. ASPL::TFE3
  2. BRAF::KIAA1549
  3. ETV6(TEL)::NTRK3
  4. MALAT1::GLI1
  5. SYT::SSX1
Board review style answer #1

Comment Here

Reference: Gastroblastoma
Board review style question #2

A large gastric antral tumor is excised in a 15 year old boy. Histologically, you identify 2 differing cellular components with spindled and epithelioid morphology (see image above). KIT, DOG1, SMA, desmin and S100 are negative. Which tumor type could this be?

  1. Gastroblastoma
  2. Gastrointestinal stromal tumor
  3. Granular cell tumor
  4. Leiomyoma
  5. Schwannoma
Board review style answer #2
A. Gastroblastoma

Comment Here

Reference: Gastroblastoma
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