MALT lymphoma

Small bowel (small intestine)
Lymphoma
MALT lymphoma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 22 February 2018, last major update August 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: MALT lymphoma[TIAB] small bowel

Table of Contents

Cite this page: Gulwani, H. MALT lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallbowelMALT.html. Accessed December 13th, 2018.

Definition / general

Tumor of Mucosa Associated Lymphoid Tissue; a type of marginal cell lymphoma
More common in stomach than small bowel
Often relapses in GI tract only
In adults, occurs anywhere in gut but only rarely in appendix and esophagus
Initially a type of hyperplasia, then monoclonal T cell dependent (from H. pylori infection), then T cell independent
Initial stages may be "cured" by antibiotics or surgery

Case reports

38 year old man with ileal MALT lymphoma with large cell component that regressed spontaneously (Gut Liver 2010;4:117)
50 year old woman with MALT related multiple lymphomatous polyposis (World J Gastroenterol 2007;13:1453)
Ileal MALT lymphoma causing massive gastrointestinal haemorrhage (Postgrad Med J 2009;85:163)

Microscopic (histologic) description

Low grade:

Small or monocytoid lymphocytes with irregular nuclei that form lymphoepithelial lesions
Reactive germinal centers and plasmacytoid cells are common

High grade:

Resembles diffuse large B cell lymphoma but may have Reed-Sternberg like cells

Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains

CD20

Negative stains

CD3, CD5, CD10, CD23, BCL1

Molecular / cytogenetics description

t(11;18) involving c-Myc is common