Small bowel (small intestine)
MALT lymphoma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 22 February 2018, last major update August 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: MALT lymphoma[TIAB] small bowel

Cite this page: Gulwani, H. MALT lymphoma. website. Accessed December 13th, 2018.
Definition / general
  • Tumor of Mucosa Associated Lymphoid Tissue; a type of marginal cell lymphoma
  • More common in stomach than small bowel
  • Often relapses in GI tract only
  • In adults, occurs anywhere in gut but only rarely in appendix and esophagus
  • Initially a type of hyperplasia, then monoclonal T cell dependent (from H. pylori infection), then T cell independent
  • Initial stages may be "cured" by antibiotics or surgery
Case reports
Microscopic (histologic) description
Low grade:
  • Small or monocytoid lymphocytes with irregular nuclei that form lymphoepithelial lesions
  • Reactive germinal centers and plasmacytoid cells are common

High grade:
  • Resembles diffuse large B cell lymphoma but may have Reed-Sternberg like cells
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Negative stains
Molecular / cytogenetics description
  • t(11;18) involving c-Myc is common