Small bowel (small intestine)
Lymphoma
MALT lymphoma


Topic Completed: 1 August 2012

Revised: 15 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: MALT lymphoma[TIAB] small bowel

Hanni Gulwani, M.B.B.S.
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Cite this page: Gulwani H. MALT lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallbowelMALT.html. Accessed October 21st, 2019.
Definition / general
  • Tumor of Mucosa Associated Lymphoid Tissue; a type of marginal cell lymphoma
  • More common in stomach than small bowel
  • Often relapses in GI tract only
  • In adults, occurs anywhere in gut but only rarely in appendix and esophagus
  • Initially a type of hyperplasia, then monoclonal T cell dependent (from H. pylori infection), then T cell independent
  • Initial stages may be "cured" by antibiotics or surgery
Case reports
Microscopic (histologic) description
Low grade:
  • Small or monocytoid lymphocytes with irregular nuclei that form lymphoepithelial lesions
  • Reactive germinal centers and plasmacytoid cells are common

High grade:
  • Resembles diffuse large B cell lymphoma but may have Reed-Sternberg like cells
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Negative stains
Molecular / cytogenetics description
  • t(11;18) involving c-Myc is common
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