Ovary tumor
Other tumors not specific to ovary
Malignant mixed mullerian tumor

Author: Nalini Gupta, M.D. (see Authors page)

Revised: 5 July 2016, last major update December 2014

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Malignant mixed mullerian tumor [title] ovary
Cite this page: Malignant mixed mullerian tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumormmt.html. Accessed December 9th, 2016.
Definition / General
  • Aggressive tumor with malignant epithelial and sarcomatous components
  • Most common in postmenopausal, low parity women
  • Very poor prognosis; stage is best predictor, and most patients present at advanced stage
Terminology
  • Malignant mixed mesodermal tumor, MMMT
Epidemiology
  • Mostly postmenopausal females, peaks in sixth decade
Sites
  • Uterus, cervix
Pathophysiology
Clinical Features
  • Abdominal mass, pain, vaginal bleeding
  • Risk factors include advanced age, excess estrogen exposure, nulliparity, prior pelvic irradiation, tamoxifen use (Lancet 2000;356:881)
Laboratory
Radiology Description
  • Pelvic ultrasound and CT: heterogeneous pelvic mass containing solid parts with/without ascites
Case Reports
Treatment
Gross Description
  • Soft and fleshy mass, often with bleeding and necrosis
Gross Images

Images hosted on Pathout server:

Contributed by Dr. Mona Kandil, Menoufiya University, Egypt:

Ovary

Uterus

Omental deposit


Micro Description
  • Malignant epithelial and sarcomatous elements
  • Sarcomatous element can be homologous (nonspecific malignant stroma) or heterologous (malignant elements of a different tissue type, particularly cartilage)
  • Often contains cytoplasmic hyaline droplets containing alpha-1-antitrypsin (Hum Pathol 1982;13:930)
  • Rarely trophoblastic tissue (Hum Pathol 1988;19:1235)
Micro Images

Images hosted on Pathout server:

Contributed by Dr. Mona Kandil, Menoufiya University, Egypt:

Malignant stroma

Necrotic foci

High grade epithelial tumor cells and necrosis

High grade malignant glands


High grade tumor cells with mitotic figures




Images hosted on other servers:

Various images

Rhabdomyosarcoma component


Heterologous elements

Positive Stains
Negative Stains
Differential Diagnosis