Ovary tumor
Other tumors not specific to ovary
Malignant mixed Müllerian tumor


Topic Completed: 1 December 2014

Revised: 14 February 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Malignant mixed Müllerian tumor [title] ovary

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Cite this page: Gupta N Malignant mixed Müllerian tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumormmt.html. Accessed October 16th, 2019.
Definition / general
  • Aggressive tumor with malignant epithelial and sarcomatous components
  • Most common in postmenopausal, low parity women
  • Very poor prognosis; stage is best predictor, and most patients present at advanced stage
Terminology
  • Malignant mixed mesodermal tumor, MMMT
Epidemiology
  • Mostly postmenopausal females, peaks in sixth decade
Sites
  • Uterus, cervix
Pathophysiology
Clinical features
  • Abdominal mass, pain, vaginal bleeding
  • Risk factors include advanced age, excess estrogen exposure, nulliparity, prior pelvic irradiation, tamoxifen use (Lancet 2000;356:881)
Laboratory
Radiology description
  • Pelvic ultrasound and CT: heterogeneous pelvic mass containing solid parts with/without ascites
Case reports
Treatment
Gross description
  • Soft and fleshy mass, often with bleeding and necrosis
Gross images

Contributed by Dr. Mona Kandil

Ovary

Uterus

Omental deposit


Microscopic (histologic) description
  • Malignant epithelial and sarcomatous elements
  • Sarcomatous element can be homologous (nonspecific malignant stroma) or heterologous (malignant elements of a different tissue type, particularly cartilage)
  • Often contains cytoplasmic hyaline droplets containing alpha-1-antitrypsin (Hum Pathol 1982;13:930)
  • Rarely trophoblastic tissue (Hum Pathol 1988;19:1235)
Microscopic (histologic) images

Contributed by Dr. Mona Kandil

Malignant stroma

Necrotic foci

High grade epithelial tumor cells and necrosis

High grade malignant glands


High grade tumor cells with mitotic figures




Images hosted on other servers:

Various images

Rhabdomyosarcoma component


Heterologous elements

Positive stains
Negative stains
Differential diagnosis
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