Colon tumor
Mesenchymal tumors
Fibromatosis of colon

Author: Raul S. Gonzalez, M.D. (see Authors page)

Revised: 20 September 2016, last major update September 2016

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Fibromatosis [title] colon

See also Soft tissue topic
Definition / General
  • Colon wall is an uncommon location for aggressive (desmoid) fibromatosis
Essential Features
  • Locally aggressive mesenchymal proliferation more commonly arising in the mesentery or retroperitoneum
  • Associated with Gardner syndrome
Terminology
  • Aggressive fibromatosis and desmoid tumor are synonyms
Clinical Features
Radiology Description
Case Reports
Treatment
  • Surgical excision, radiation therapy, possibly chemotherapy
Clinical Images

Images hosted on other servers:

Colonic desmoid on PET / CT

Gross Description
  • Firm, tan, homogenous
  • Usually large (up to 25 cm) with infiltrative borders
Micro Description
  • Broad, sweeping fascicles of bland spindle cells with low mitotic activity, bland nuclear features, finely collagenous stroma with evenly spaced blood vessels and infiltrative borders
  • Tumor may extend through colonic wall up to muscularis propria
  • No necrosis, no hemorrhage, no pleomorphism, no myxoid degeneration, no epithelioid cells, no foam cells
Micro Images

Images hosted on PathOut servers:

Courtesy of Raul S. Gonzalez, M.D.

Positive Stains
Negative Stains
Electron Microscopy Description
  • Myofibroblastic / fibroblastic differentiation
Molecular / Cytogenetics Description
Differential Diagnosis