Ovary tumor
Sex cord stromal tumors

Author: Shahrzad Ehdaivand, M.D. (see Authors page)

Revised: 11 July 2016, last major update December 2014

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Ovary Fibroma [title]

See also: Cellular fibroma, With minor sex cord elements
Cite this page: Fibroma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorfibroma.html. Accessed February 21st, 2018.
Definition / general
  • Common; benign; arise after puberty
  • 40% of tumors > 6 cm are associated with ascites
  • Also associated with right sided hydrothorax, Meigs syndrome and basal cell nevus syndrome
  • Meigs syndrome: ovarian fibromas, right sided hydrothorax, ascites; after tumor excision, hydrothorax and ascites disappear
  • Basal cell nevus syndrome (Gorlin syndrome): autosomal dominant disease of multiple basal cell carcinomas, odontogenic keratocysts, palmoplantar pits, congenital skeletal abnormalities and ectopic calcifications, caused by mutational inactivation of the PTCH gene; also have calcified, bilateral, often multinodular ovarian fibromas
  • Fibrothecoma: combined fibroma and thecoma; also a generalized term for these two closely related tumors
  • References: Am J Surg Pathol 2002;26:1477
Case reports
  • Excision, does not recur
Gross description
  • Mean 6 cm, usually unilateral, solid, lobulated, firm, white and may have myxoid change
  • Not associated with adhesions
Gross images
Images hosted on PathOut server:

Various images

Images hosted on other servers:

Ovarian stromal tumor


Right adnexal, 12.5 10 9 cm mass
with attached fallopian tube;
white-tan and smooth,
with focal areas of hemorrhage

Microscopic (histologic) description
  • Closely packed spindle cells in "feather-stitched" or storiform pattern
  • May have hyaline bands and edema; no atypia
Microscopic (histologic) images
Images hosted on PathOut server:

Storiform pattern

Lacking atypia or mitotic activity

Prominent intercellular edema

Numerous hyaline droplets

Images hosted on other servers:

Fibrothecoma with focal
fibrosarcomatous area

Fig 2: moderate cellularity with calcification;
Fig 3: moderate pale vacuolated cytoplasm and oval nuclei;
Fig 4: focal hypercellular foci with spindle cells in fascicles, no mitotic figures

Positive stains
Molecular / cytogenetics description
  • Trisomy 12
Differential diagnosis