Skin - Melanocytic tumor
Melanoma
Melanoma in situ

Author: Christopher Hale, M.D. (see Authors page)

Revised: 21 February 2017, last major update April 2013

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Melanoma in situ

Cite this page: Melanoma in situ. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skintumormelanocyticmelanomainsitu.html. Accessed February 25th, 2017.
Definition / General
  • Malignant melanocytes in epidermis, without dermal invasion
  • Variants include lentigo maligna, superficial spreading and acral melanoma
Epidemiology
Clinical Features
  • Cases in sun damaged skin may resemble benign lichenoid keratosis (Hum Pathol 2003;34:706)
  • Characterized by pagetoid spread, confluence and nesting of atypical melanocytes
  • May be associated with invasive malignant melanoma (Hum Pathol 2000;31:705)
  • Large pigmented lesions, irregular margins and irregular pigmentation
  • Hutchinson sign: periungual extension of brownish black pigmentation from longitudinal melanonychia (pigmented stripe within length of nail bed) onto the proximal and lateral nailfolds
Case Reports
Treatment
Dermoscopy
Clinical Images

Images hosted on other servers:

Various images

Acral lesion with parallel ridge pattern (B)


Before and after Imiquimod cream (A, B)

Various images

Micro Description
  • Atypical melanocytes in epidermis with no dermal invasion
  • Usually epidermal effacement (absences of rete ridges in some foci, J Drugs Dermatol 2007;6:708)
  • Predominance of individual unit melanocytes over nests
  • Confluent growth of melanocytes along dermoepidermal junction
  • Pagetoid spread
  • Involvement of adnexal structures
Micro Images

Images hosted on PathOut server:

Hyperkeratotic keratosis with coexisting melanoma in situ and MITF staining

Melanoma in situ


Fibrohistiocytic proliferation extending to epidermis

Frozen section from Mohs procedure

Limited pagetoid spread in nail

Videos


Melanoma in situ
Differential Diagnosis