WHO HAEM4R
| WHO HAEM5
| ICC
|
Tumor-like lesions with B cell proliferation
|
Not included
| Reactive B cell rich lymphoid proliferations that can mimic lymphoma
|
|
Not included
| IgG4 related disease
|
|
Not included
| Unicentric Castleman disease
|
|
Not included
| Idiopathic multicentric Castleman disease
|
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Multicentric Castleman disease
| KSHV / HHV8 associated multicentric Castleman disease
| Multicentric Castleman disease
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Not included
|
| EBV positive polymorphic B cell lymphoproliferative disorder, NOS
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Neoplastic and preneoplastic small lymphocytic proliferation
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Chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL / SLL)
| Chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL / SLL)
| Chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL / SLL)
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Monoclonal B cell lymphocytosis - CLL type
- Atypical CLL type
- Non-CLL type
| Monoclonal B cell lymphocytosis - Low count or clonal B cell expansion
- CLL / SLL type
- Non-CLL / SLL type
| Monoclonal B cell lymphocytosis
|
B prolymphocytic leukemia (B PLL)
| Not a distinct entity but heterogeneous
| B prolymphocytic leukemia (B PLL)
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Lymphoplasmacytic lymphoma- Waldenström macroglobulinemia
| Lymphoplasmacytic lymphoma - Waldenström macroglobulinemia
- Non-Waldenström macroglobulinemia
| Lymphoplasmacytic lymphoma - Waldenström macroglobulinemia
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Marginal zone lymphoma
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Nodal marginal zone lymphoma
| Nodal marginal zone lymphoma
| Nodal marginal zone lymphoma
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Pediatric nodal marginal zone lymphoma*
| Pediatric nodal marginal zone lymphoma
| Pediatric nodal marginal zone lymphoma*
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Extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT)
| Extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT)
| Extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT)
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Not included; part of extranodal marginal zone lymphoma of MALT
| Primary cutaneous marginal zone lymphoma
| Primary cutaneous marginal zone lymphoproliferative disorder
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Splenic B cell lymphoma / leukemia
|
Splenic marginal zone lymphoma
| Splenic marginal zone lymphoma
| Splenic marginal zone lymphoma
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Hairy cell leukemia
| Hairy cell leukemia
| Hairy cell leukemia
|
Hairy cell leukemia variant*
| Splenic B cell lymphoma / leukemia with prominent nucleoli (distinct from HCL and includes all previous CD5 negative B PLL)
| Hairy cell leukemia variant*
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Splenic diffuse red pulp small B cell lymphoma*
| Splenic diffuse red pulp small B cell lymphoma
| Splenic diffuse red pulp small B cell lymphoma*
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Follicular lymphoma
|
In situ follicular neoplasia
| In situ follicular B cell neoplasm
| In situ follicular neoplasia
|
Follicular lymphoma (FL)
| Follicular lymphoma (grading of cFL not mandatory) - Classic follicular lymphoma (cFL)
- Follicular large B cell lymphoma (FLBL)
- Follicular lymphoma with uncommon features (uFL)
| Follicular lymphoma (continue grading FL with emphasis on 3A and 3B) - Follicular lymphoma
- BCL2 rearrangement negative, CD23 positive follicle center lymphoma*
|
Pediatric type follicular lymphoma
| Pediatric type follicular lymphoma
| Pediatric type follicular lymphoma
|
Not included
|
| Testicular follicular lymphoma
|
Duodenal type follicular lymphoma
| Duodenal type follicular lymphoma
| Duodenal type follicular lymphoma
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Primary cutaneous follicle center lymphoma
| Primary cutaneous follicle center lymphoma
| Primary cutaneous follicle center lymphoma
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Mantle cell lymphoma
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In situ mantle cell neoplasia
| In situ mantle cell neoplasia
| In situ mantle cell neoplasia
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Mantle cell lymphoma
| Mantle cell lymphoma
| Mantle cell lymphoma
|
Leukemic nonnodal mantle cell lymphoma
| Leukemic nonnodal mantle cell lymphoma
| Leukemic nonnodal mantle cell lymphoma
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Aggressive lymphomas transformed from low grade B cell lymphomas
|
Not included
| Transformations of indolent B cell lymphomas
|
|
Large B cell lymphoma
|
Diffuse large B cell lymphoma (DLBCL), NOS
| Diffuse large B cell lymphoma, NOS
| Diffuse large B cell lymphoma, NOS
|
EBV positive mucocutaneous ulcer*
| EBV positive mucocutaneous ulcer
| EBV positive mucocutaneous ulcer
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EBV positive diffuse large B cell lymphoma, NOS
| EBV positive diffuse large B cell lymphoma
| EBV positive diffuse large B cell lymphoma, NOS
|
Diffuse large B cell lymphoma associated with chronic inflammation
| Diffuse large B cell lymphoma associated with chronic inflammation
| Diffuse large B cell lymphoma associated with chronic inflammation
|
Primary large B cell lymphoma of the central nervous system
| Primary large B cell lymphoma of immune privileged sites (new umbrella term for DLBCL arising in the CNS, vitreoretina and testis)
| Primary diffuse large B cell lymphoma of central nervous system
|
Not included
| Primary diffuse large B cell lymphoma of testis
|
Primary cutaneous diffuse large B cell lymphoma, leg type
| Primary cutaneous diffuse large B cell lymphoma, leg type
| Primary cutaneous diffuse large B cell lymphoma, leg type
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Intravascular large B cell lymphoma
| Intravascular large B cell lymphoma
| Intravascular large B cell lymphoma
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ALK positive large B cell lymphoma
| ALK positive large B cell lymphoma
| ALK positive large B cell lymphoma
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Plasmablastic lymphoma
| Plasmablastic lymphoma
| Plasmablastic lymphoma
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Large B cell lymphoma with IRF4 rearrangement
| Large B cell lymphoma with IRF4 rearrangement
| Large B cell lymphoma with IRF4 rearrangement
|
Primary mediastinal large B cell lymphoma
| Primary mediastinal large B cell lymphoma
| Primary mediastinal large B cell lymphoma
|
B cell lymphoma, unclassified with features intermediate between DLBCL and classic Hodgkin lymphoma
| Mediastinal gray zone lymphoma (cases without mediastinal involvement are classified as DLBCL, NOS)
| Mediastinal gray zone lymphoma
|
Not included
| Fibrin associated large B cell lymphoma
| Fibrin associated large B cell lymphoma
|
Not included
| Fluid overload associated large B cell lymphoma (previously included in primary effusion lymphoma)
| HHV8 and EBV8 negative primary effusion based lymphoma*
|
T cell / histiocyte rich large B cell lymphoma
| T cell / histiocyte rich large B cell lymphoma
| T cell / histiocyte rich large B cell lymphoma
|
See Hodgkin lymphomas
| See Hodgkin lymphomas
| Nodular lymphocyte predominant B cell lymphoma (renamed from nodular lymphocyte predominant Hodgkin lymphoma)
|
Lymphomatoid granulomatosis
| Lymphomatoid granulomatosis
| Lymphomatoid granulomatosis
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KSHV / HHV8 associated B cell lymphoid proliferation / lymphoma
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Primary effusion lymphoma
| Primary effusion lymphoma
| Primary effusion lymphoma
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HHV8 positive diffuse large B cell lymphoma, NOS
| HHV8 positive diffuse large B cell lymphoma
| HHV8 positive diffuse large B cell lymphoma, NOS
|
HHV8 positive germinotropic lymphoproliferative disorder
| KSHV / HHV8 positive germinotropic lymphoproliferative disorder
| HHV8 positive germinotropic lymphoproliferative disorder
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High grade B cell lymphomas
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High grade B cell lymphoma, NOS
| High grade B cell lymphoma, NOS
| High grade B cell lymphoma, NOS
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High grade B cell lymphoma with MYC and BCL2 or BCL6 rearrangements
| Diffuse large B cell lymphoma / high grade B cell lymphoma with MYC and BCL2 rearrangements (previous high grade B cell lymphoma with MYC and BCL6 rearrangements is designated as DLBCL, NOS)
| High grade B cell lymphoma with MYC and BCL2 rearrangements
|
High grade B cell lymphoma with MYC and BCL6 rearrangements*
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Burkitt lymphoma
| Burkitt lymphoma (EBV status supersedes epidemiologic subtyping)
| Burkitt lymphoma
|
Burkitt-like lymphoma with 11q aberration*
| High grade B cell lymphoma with 11q aberration
| Large B cell lymphoma with 11q aberration*
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Hodgkin lymphomas
|
Classic Hodgkin lymphoma - Nodular sclerosis
- Lymphocyte rich
- Mixed cellularity
- Lymphocyte depleted
| Classic Hodgkin lymphoma - Nodular sclerosis
- Lymphocyte rich
- Mixed cellularity
- Lymphocyte depleted
| Classic Hodgkin lymphoma - Nodular sclerosis
- Lymphocyte rich
- Mixed cellularity
- Lymphocyte depleted
|
Nodular lymphocyte predominant Hodgkin lymphoma
| Nodular lymphocyte predominant Hodgkin lymphoma
| Renamed as nodular lymphocyte predominant B cell lymphoma; categorized as non-Hodgkin lymphoma
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Plasma cell neoplasms and entities with paraproteins
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Solitary plasmacytoma of bone
| Solitary plasmacytoma of bone
| Solitary plasmacytoma of bone
|
Extraosseous plasmacytoma
| Extraosseous plasmacytoma
| Extraosseous plasmacytoma
|
Plasma cell myeloma
| Plasma cell myeloma
| Multiple myeloma (MM), NOS
|
MM with recurrent genetic abnormality - MM with CCND family translocation
- MM with MAF family translocation
- MM with NSD2 family translocation
- MM with hyperdiploidy
|
Plasma cell neoplasm with associated paraneoplastic syndrome
| Plasma cell neoplasm with associated paraneoplastic syndrome - POEMS
- TEMPI
- AESOP (new syndrome)
|
|
IgM monoclonal gammopathy of undetermined significance
| IgM monoclonal gammopathy of undetermined significance
| IgM monoclonal gammopathy of undetermined significance - IgM MGUS, plasma cell type
- IgM MGUS, NOS
|
Non-IgM monoclonal gammopathy of undetermined significance
| Non-IgM monoclonal gammopathy of undetermined significance
| Non-IgM monoclonal gammopathy of undetermined significance
|
Not included
| Monoclonal gammopathy of renal significance
| Not a separate entity; clinical descriptor of the underlying diagnosis (e.g., MGUS)
|
Not included
| Cold agglutinin disease
| Primary cold agglutinin disease
|
Primary amyloidosis
| Immunoglobulin related (AL) amyloidosis
| Immunoglobulin light chain (AL) amyloidosis
|
Localized AL amyloidosis
|
Light chain and heavy chain deposition disease
| Monoclonal immunoglobulin deposition disease (renamed)
| Light chain and heavy chain deposition
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Mu heavy chain disease
| Mu heavy chain disease
| Mu heavy chain disease
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Gamma heavy chain disease
| Gamma heavy chain disease
| Gamma heavy chain disease
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Alpha heavy chain disease
| Alpha heavy chain disease
| Alpha heavy chain disease
|
Lymphoid proliferations / lymphomas with immune deficiency or dysregulation
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Nondestructive PTLD
| Hyperplasias arising in immune deficiency / dysregulation
| Plasmacytic hyperplasia PTLD
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Florid follicular hyperplasia PTLD
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Infectious mononucleosis PTLD
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Polymorphic PTLD
| Polymorphic lymphoproliferative disorders arising in immune deficiency / dysregulation (new term that includes various etiologies)
| Polymorphic PTLD
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Other iatrogenic immunodeficiency associated lymphoproliferative disorders | Other iatrogenic immunodeficiency associated lymphoproliferative disorders
|
Monomorphic PTLD
| Lymphomas arising in immune deficiency / dysregulation (new umbrella term that includes monomorphic PTLD, lymphomas associated with HIV infection, etc.)
| Monomorphic PTLD
|
Classic Hodgkin lymphoma PTLD
| Classic Hodgkin lymphoma PTLD
|
Lymphomas associated with HIV infection
|
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Lymphoproliferative diseases associated with primary immune disorders
| Inborn error of immunity associated lymphoid proliferations and lymphomas
|
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